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Sildenafil can be a strong and selective inhibitor of cGMP distinct phosphodiesterase form 5 (PDE5) in the corpus cavernosum, where by PDE5 is answerable for degradation of cGMP. Sildenafil provides a peripheral site of motion on erections. Sildenafil has no immediate relaxant effect on isolated human corpus cavernosum but potently improves the rel